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In a cell-free liposomeliposome contact system, iron-dependent lipid peroxidation could be transmitted between directly apposed bilayers in the absence of cytosolic signaling components, indicating that the oxidized membrane state itself can, under appropriate conditions, propagate across closely juxtaposed membranes

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doi: 10.1023/a:1015399204069 77 HanadaKUchidaTTsukamotoYWatadaMYamaguchiNYamamotoKet al

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Damaged mitochondria leak excess electrons, causing an explosion of ROS that completely overwhelms the cell's antioxidant capacity